Malaria kills close to a million people yearly. It is most prevalent in countries in Africa, Latin America and Asia (Breman , 2004). The Plasmodium parasites in mosquitoes that cause malaria can be transmitted to humans by mosquito vectors of the genus Anopheles. A female mosquito bite transfers the parasite from an infected Anopheles mosquito to the human body and the Plasmodium sporozoites eventually make their way to the liver (Sinnis, 2007). The life cycle of sporozoites both in the mosquito as well as the host cell is important to consider because each step determines infection (Mota, 2001). Sporozoites are made and released in the mosquito midgut; they bind to the salivary glands and inhabit their secretory cells. Once they enter the mammalian host cell, they travel to the liver and traverse multiple cells until successfully invading hepatocytes (Coppi, 2007). Without successful invasion of hepatocytes, the infection is not viable.
Greetings, Class of 2010! Two thousand ten – that has a nice ring to it. I am honored to have an opportunity to address this entering medical school class at Meharry Medical College. You should be commended on your accomplishments. Acceptance to medical school is a big deal – this is a tremendous accomplishment. It is a time of celebration for students, parents and friends. Thank you for inviting me to celebrate with you and participate in today’s event. I have had an opportunity to reflect on my own emotional state nearly 22 years ago when I entered medical school. I was filled with overwhelming excitement and nearly paralyzing anxiety. I suspect that as you sit here today, you too are filled with a myriad of emotions – joy, excitement, anxiety. It is my goal today to help you strip away all anxiety and nervousness and to help you develop a strategy to achieve your ultimate goal of becoming a doctor.